Hydrogen Review Articles

Zhang, Y., et al., Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside. Cell Physiol Biochem, 2018. 47(1): p. 1-10.

Sano, M., et al., Promising novel therapy with hydrogen gas for emergency and critical care medicine. Acute Med Surg, 2018. 5(2): p. 113-118.

Yoritaka, A., et al., Erratum to: A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurol, 2017. 17(1): p. 35.

Ostojic, S.M., Non-gut microbiota as a source of bioactive hydrogen. Postgrad Med J, 2017. 93(1097): p. 170.

Ostojic, S.M., Does H2 Alter Mitochondrial Bioenergetics via GHS-R1alpha Activation? Theranostics, 2017. 7(5): p. 1330-1332.

Nakayama, M., et al., Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation. PLoS One, 2017. 12(9): p. e0184535.

Li, Q., et al., Fundamental Insight into the Methodology of Hydrogen Water in Biological Studies. Journal of Nanoscience and Nanotechnology, 2017. 17(7): p. 5134-5138.

Li, H.M., et al., The transfer of hydrogen from inert gas to therapeutic gas. Med Gas Res, 2017. 7(4): p. 265-272.

Li, F., et al., Potential protective role of hydrogen against cisplatininduced side effects during chemotherapy: A mini-review of a novel hypothesis for antagonism of hydrogen. Tropical Journal of Pharmaceutical Research, 2017. 16(11): p. 2773-2776.

Iketani, M. and I. Ohsawa, Molecular Hydrogen as a Neuroprotective Agent. Curr Neuropharmacol, 2017. 15(2): p. 324-331.

Ge, L., et al., Molecular hydrogen: a preventive and therapeutic medical gas for various diseases. Oncotarget, 2017. 8(60): p. 102653-102673.

Dohi, K., et al., Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration. J Clin Biochem Nutr, 2017. 61(1): p. 1-5.

Asfandiarov, N.L., et al., Dissociative electron attachment to some spinochromes: Fragment anion formation. International Journal of Mass Spectrometry, 2017. 412: p. 26-37.

Ara, J., et al., Potential therapeutic effect of alkaline reduced water in polycystic ovarian syndrome. Med Hypotheses, 2017. 104: p. 36-39.

Yuan, L. and J. Shen, Hydrogen, a potential safeguard for graft-versus-host disease and graft ischemia-reperfusion injury? Clinics (Sao Paulo), 2016. 71(9): p. 544-9.

Yoritaka, A., et al., A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurol, 2016. 16: p. 66.

Tao, Y., et al., The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases. Ther Clin Risk Manag, 2016. 12: p. 799-806.

Tao, Y., et al., Use of Hydrogen as a Novel Therapeutic Strategy Against Photoreceptor Degeneration in Retinitis Pigmentosa Patients. Med Sci Monit, 2016. 22: p. 776-9.

Slezak, J., et al., Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals. Physiol Res, 2016. 65 Suppl 1: p. S11-28.

Qin, L., et al., Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis. Med Sci Monit, 2016. 22: p. 3191-5.

Ostojic, S.M. and A. Vojvodic-Ostojic, Is melanin a source of bioactive molecular hydrogen? Pharmacol Res, 2016. 103: p. 177-9.

Nicolson, G.L., et al., Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine. International Journal of Clinical Medicine, 2016. 7(1).

Nakayama, M., S. Kabayama, and S. Ito, The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives. Renal Replacement Therapy, 2016. 2(1): p. 23.

Liu, C.L., K. Zhang, and G. Chen, Hydrogen therapy: from mechanism to cerebral diseases. Med Gas Res, 2016. 6(1): p. 48-54.

Iida, A., et al., The Clinical Application of Hydrogen as a Medical Treatment. Acta Med Okayama, 2016. 70(5): p. 331-337.

Huang, L., Molecular hydrogen: a therapeutic antioxidant and beyond. Med Gas Res, 2016. 6(4): p. 219-222.

Fan, D.F., et al., Oral administration of lactulose: a novel therapy for acute carbon monoxide poisoning via increasing intestinal hydrogen production. Undersea Hyperb Med, 2016. 43(1): p. 45-8.

Chen, O., Z.-h. Y., and C. Li., Meeting report: Second Hydrogen Molecule Biomedical Symposium in Beijing, China. Medical Gas Research, 2016. 6(1): p. 57.

Camara, R., L. Huang, and J.H. Zhang, The production of high dose hydrogen gas by the AMS-H-01 for treatment of disease. Med Gas Res, 2016. 6(3): p. 164-166.

Zhai, X., A. Nakao, and X. Sun, Detection Techniques for Hydrogen. Hydrogen Molecular Biology and Medicine. 2015: Springer Netherlands.

Shi, Q.H., et al., Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment. Biomed Environ Sci, 2015. 28(3): p. 239-41.

Qian, L., J. Shen, and X. Sun, Therapeutic Effects of Hydrogen on Different Diseases. Hydrogen Molecular Biology and Medicine. 2015: Springer Netherlands. 81-97.

Qian, L., J. Shen, and X. Sun, Methods of Hydrogen Application. Hydrogen Molecular Biology and Medicine. 2015: Springer Netherlands.

Pshenichnyuk, S.A. and A.S. Komolov, Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H2 Antioxidant Species Inside Mitochondria. The Journal of Physical Chemistry Letters, 2015. 6(7): p. 1104-1110.

Pshenichnyuk, S.A., et al., Low-energy electron interaction with retusin extracted from Maackia amurensis: towards a molecular mechanism of the biological activity of flavonoids. Phys Chem Chem Phys, 2015. 17(26): p. 16805-12.

Ostojic, S.M., Molecular hydrogen in sports medicine: new therapeutic perspectives. Int J Sports Med, 2015. 36(4): p. 273-9.

Ostojic, S.M., Molecular hydrogen: An inert gas turns clinically effective. Ann Med, 2015: p. 1-4.

Ostojic, S.M., Eumelanin-driven production of molecular hydrogen: A novel element of skin defense? Med Hypotheses, 2015.

Ostojic, S.M., Targeting molecular hydrogen to mitochondria: Barriers and gateways. Pharmacol Res, 2015. 94: p. 51-3.

Ohta, S., Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications. Methods Enzymol, 2015. 555: p. 289-317.

McCarty, M.F., Potential ghrelin-mediated benefits and risks of hydrogen water. Med Hypotheses, 2015. 84(4): p. 350-5.

Liu, W., X. Sun, and S. Ohta, Hydrogen Element and Hydrogen Gas. Hydrogen Molecular Biology and Medicine. 2015: Springer Netherlands.

Kurokawa, R., et al., Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation. Med Gas Res, 2015. 5: p. 13.

Ichihara, M., et al., Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles. Med Gas Res, 2015. 5: p. 12.

Chen, Y., et al., Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw. Ther Clin Risk Manag, 2015. 11: p. 1581-5.

Chen, X., X. Sun, and S. Ohta, Future Directions in Hydrogen Studies. Hydrogen Molecular Biology and Medicine. 2015: Springer Netherlands.

Zhai, X., et al., Review and prospect of the biomedical effects of hydrogen. Med Gas Res, 2014. 4(1): p. 19.

Zeng, J., Z. Ye, and X. Sun, Progress in the study of biological effects of hydrogen on higher plants and its promising application in agriculture. Med Gas Res, 2014. 4: p. 15.

Yang, F., et al., Simulation study on the outlet flow dynamics of a hydride-based hydrogen storage canister for medical use. International Journal of Hydrogen Energy 2014. 39(12): p. 6548-6557.

Xie, F. and X. Ma, Molecular Hydrogen and its Potential Application in Therapy of Brain Disorders. Brain Disord Ther, 2014: p. 2.

Wang, R., Gasotransmitters: growing pains and joys. Trends Biochem Sci, 2014. 39(5): p. 227-32.

Shen, M., et al., A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine. Med Gas Res, 2014. 4: p. 17.

Ostojic, S.M., Molecular Hydrogen in Sports Medicine: New Therapeutic Perspectives. Int J Sports Med, 2014.

Ohta, S., Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther, 2014.

Gopinath, D., et al., MOLECULAR HYDROGEN THERAPY: A MAJOR MILESTONE IN MEDICINE. World Journal of Pharmacy and Pharmaceutical Sciences, 2014. 3(8): p. 1201-1205.

Deng, J., et al., Neuroprotective gases–fantasy or reality for clinical use? Prog Neurobiol, 2014. 115: p. 210-45.

Brenner, S., Parkinson’s disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress. Med Hypotheses, 2014. 82(4): p. 503.

Qu, J. and X. Lu, Hydrogen: A promising novel treatment for hepatic encephalopathy? Free Radic Biol Med, 2013.

Qian, L., et al., Hydrogen as a New Class of Radioprotective Agent. International journal of biological sciences, 2013. 9(9): p. 887-894.

Lucas, K. and M. Maes, Molecular mechanisms underpinning laser printer and photocopier induced symptoms, including chronic fatigue syndrome and respiratory tract hyperresponsiveness: pharmacological treatment with cinnamon and hydrogen. Neuro Endocrinol Lett, 2013. 34(8): p. 723-37.

Henry, M. and J. Chambron, Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW). Water 5(4): p. 2094-2115.

Ghanizadeh, A. and M. Berk, Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia. Med Gas Res, 2013. 3(1): p. 11.

Dixon, B.J., J. Tang, and J.H. Zhang, The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance. Med Gas Res, 2013. 3(1): p. 10.

Chang, W.J. and L.H. Toledo-Pereyra, The potential benefits of hydrogen-rich saline in ischemia and reperfusion injury. Journal of Surgical Research, 2013. 180(2): p. 248-9.

Zhou, J., et al., Targeting gaseous molecules to protect against cerebral ischaemic injury: mechanisms and prospects. Clinical and Experimental Pharmacology and Physiology, 2012. 39(6): p. 566-76.

Zhang, J.Y., et al., A Review of Hydrogen as a New Medical Therapy. Hepato-Gastroenterology, 2012. 59(116): p. 1026-1032.

Zhang, D.Q., J.H. Zhu, and W.C. Chen, Acarbose: a new option in the treatment of ulcerative colitis by increasing hydrogen production. Afr J Tradit Complement Altern Med, 2012. 10(1): p. 166-9.

Simon, A.R., Hydrogen-supplemented drinking water, just soda or an elixir of life? Transplant International, 2012. 25(12): p. 1211-1212.

Shirahata, S., T. Hamasaki, and K. Teruya, Advanced research on the health benefit of reduced water. Trends in Food Science & Technology, 2012. 23(2): p. 124-131.

Shi, P. and W. Sun, A hypothesis on chemical mechanism of the effect of hydrogen. Med Gas Res, 2012. 2(1): p. 17.

Seo, T., R. Kurokawa, and B. Sato, A convenient method for determining the concentration of hydrogen in water: use of methylene blue with colloidal platinum. Medical Gas Research, 2012. 2: p. 1.

Schoenfeld, M.P., et al., A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures. Medical Gas Research, 2012. 2: p. 8.

Rheem, K.E., et al., Does alkaline-reduced hexagonal water delay the aging process in Drosophila? Geriatr Gerontol Int, 2012. 12(1): p. 151-4.

Ostojic, S.M., Serum alkalinization and hydrogen-rich water in healthy men. Mayo Clin Proc, 2012. 87(5): p. 501-2.

Ohta, S., Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Biochimica et Biophysica Acta, 2012. 1820(5): p. 586-94.

Ohno, K., M. Ito, and M. Ichihara, Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxidative Medicine and Cellular Longevity, 2012. 2012: p. 353152.

Liu, S., X. Sun, and H. Tao, Hydrogen from a biologically inert gas to a unique antioxidant. Second Military Medical University, www.intechopen., 2012.

Li, D. and W.C. Wang, Can hydrogen retard the progression of osteoarthritis? African Journal of Pharmacy and Pharmacology, 2012. 6(5): p. 352-354.

Hardeland, R., Hydrogen therapy: a future option in critical care? Crit Care Med, 2012. 40(4): p. 1382-3.

Ghanizadeh, A., Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production. Medical Gas Research, 2012. 2(1): p. 19.

Ghanizadeh, A., Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism. European Review for Medical and Pharmacological Sciences, 2012. 16(9): p. 1313-4.

Chuai, Y., et al., Molecular hydrogen and radiation protection. Free Radical Research, 2012. 46(9): p. 1061-7.

Shen, Y., et al., Hydrogen gas: a novel antioxidant for chronic obstructive pulmonary disease. Journal of Medical Colleges of PLA, 2011. 26(2): p. 94-97.

Schoenfeld, M.P., et al., Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. Medical Hypotheses, 2011. 76(1): p. 117-8.

Ohta, S., A. Nakao, and K. Ohno, The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research Medical Gas Research, 2011. 1: p. 10.

Ohta, S., Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des, 2011. 17(22): p. 2241-52.

Chuai, Y., et al., A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution. Medical Science Monitor, 2011. 17(4): p. HY1-4.

Chen, J., et al., Hydrogen therapy may be a promising, safe and effective treatment for diabetic erectile dysfunction: a hypothesis. Alternative Medicine Studies, 2011. 1(1): p. 11.

Qian, L.R., et al., The Hypothesis of an Effective Safe and Novel Radioprotective Agent Hydrogen-rich Solution. West Indian Medical Journal, 2010. 59(2): p. 122-124.

Qian, L., et al., The potential cardioprotective effects of hydrogen in irradiated mice. J Radiat Res, 2010. 51(6): p. 741-7.

Liu, C., et al., Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical Hypotheses, 2010. 74(1): p. 145-146.

Huang, C.S., et al., Recent advances in hydrogen research as a therapeutic medical gas. Free Radical Research, 2010. 44(9): p. 971-982.

Hong, Y., S. Chen, and J.M. Zhang, Hydrogen as a selective antioxidant: a review of clinical and experimental studies. Journal of International Medical Research, 2010. 38(6): p. 1893-903.

Goncharuk, V.V., et al., The use of redox potential in water treatment processes. Journal of Water Chemistry and Technology, 2010. 32(1): p. 1-9.

George, J.F. and A. Agarwal, Hydrogen: another gas with therapeutic potential. Kidney International, 2010. 77(2): p. 85-87.

Nakao, A., et al., Therapeutic Antioxidant Medical Gas. Journal of Clinical Biochemistry and Nutrition, 2009. 44(1): p. 1-13.

Milton, S.L., Hydrogen Saline a Real Gas. Journal of Experimental Biology, 2009. 212(15): p. v-vi.

Ohta, S., [Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept]. Nihon Ronen Igakkai Zasshi, 2008. 45(4): p. 355-62.

Jun, X.S. and H. Zhang, Hydrogen-an endogenous antioxidant in the body. Academic Journal of Second Military Medical University 28(3): p. 233-235.

Wood, K.C. and M.T. Gladwin, The hydrogen highway to reperfusion therapy. Nat Med, 2007. 13(6): p. 673-674.

Ball, J., Recently published papers: More about EGDT, experimental therapies and some inconvenient truths. Critical Care, 2007. 11(5).

Shirahata, S.A.N.E.T.A.K.A., Reduced water for prevention of diseases. Animal Cell Technology: Basic and Applied Aspects 2002. 12: p. 25-30.

Okouchi, S., et al., Water desirable for the human body in terms of oxidation-reduction potential (ORP) to pH relationship. Journal of Food Science, 2002. 67(5): p. 1594-1598.

Kumon, K., What Is Functional Water? Artificial Organs, 1997. 21(1): p. 2-4.

Jones, D., Gas Therapy. Nature 1996. 383: p. 676.

Nakamura, D.N., Hydrogen, What a Gas. Hydrocarbon Processing, 1993. 72(11): p. 23-23.

Cavallo, T., An essay on the medicinal properties of factitious airs: with an appendix on the nature of blood. 1798: Printed for the author, and sold by C. Dilly [and 2 others].

These scientific articles, although promising and interesting, do not constitute clinical guidelines that hydrogen can cure or prevent a specific disease. Consult your medical health provider for medical questions.